Different Effects between Antihypertensive Drugs on Nephrotic-Range Proteinuria in Renovascular Hypertension
作者:
Toshihiko Ishimitsu,
Hiroshi Yagi,
Masaaki Ohkubo,
Yasuyuki Nakamura,
Shigeru Yagi,
期刊:
American Journal of Nephrology
(Karger Available online 1994)
卷期:
Volume 14,
issue 1
页码: 60-63
ISSN:0250-8095
年代: 1994
DOI:10.1159/000168687
出版商: S. Karger AG
关键词: Proteinuria;Renovascular hypertension;Calcium channel blockers;Angiotensin-converting enzymeinhibitors;Beta-blockers
数据来源: Karger
摘要:
A 61-year-old man developed renovascular hypertension characterized by nephrotic-range proteinuria. When he was treated with a calcium channel blocker, glomerular filtration fraction was 0.26 and massive proteinuria ranging from 10 to 15 g/day persisted. An angiotensin-converting enzyme inhibitor markedly reduced the proteinuria to 1-2 g/day with a filtration fraction of 0.20. After the antihypertensive drug was switched to a β-blocker, the filtration fraction was 0.23 and urinary protein excretion was 3-4 g/day. Blood pressure control was comparable by each drug. These findings suggest a role of intraglomerular hydraulic mechanism in the etiology of massive proteinuria in renovascular hypertension
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