Respiratory cytopathology in chlorine gas toxicity: A study in 28 subjects
作者:
Chandralekha P. Shroff,
Megha V. Khade,
Mahalaxmi Srinivasan,
期刊:
Diagnostic Cytopathology
(WILEY Available online 1988)
卷期:
Volume 4,
issue 1
页码: 28-32
ISSN:8755-1039
年代: 1988
DOI:10.1002/dc.2840040108
出版商: Wiley Subscription Services, Inc., A Wiley Company
关键词: Bronchial brushing;Chlorine gas toxicity;“Irritation forms” of respiratory epithelium;Chromatolysis;Columnar epithelial cell syncytia;Nonpigmented alveolar macrophage;Epithelial regeneration;Repair by fibrosis
数据来源: WILEY
摘要:
AbstractBronchial brushings to evaluate cytopathologic changes were collected from 28 patients exposed to a toxic atmospheric level (66 parts/million) of chlorine gas. Postexposure smears collected on day 5 showed basal‐cell and goblet‐cell hyperplasia, acute inflammation, and chromatolysis of columnar epithelial cells. Columnar epithelial cell syncytia were observed in 15 (53.57%) smears. Nine (32.14%) smears showed abundant nonpigmented alveolar macrophages. Seven (25%) smears from mucosal erosions showed proliferating fibroblasts and capillary fragments; on day 15 and day 25 repeat smears from these seven cases showed evidence of epithelial regeneration and repair byfibrosis. This latter feature could lead to chronic ventilatory incapacitation in patients exposed to toxic levels of chlorine
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