Leukocyte Adherence Inhibition Microtest for the Detection of Cell-Mediated Immunity to Tumor in Gastric Cancer Patients
作者:
S. Koyama,
T. Sakita,
H. Fukutomi,
I. Kawakita,
N. Tamura,
期刊:
Oncology
(Karger Available online 1981)
卷期:
Volume 38,
issue 1
页码: 13-17
ISSN:0030-2414
年代: 1981
DOI:10.1159/000225513
出版商: S. Karger AG
关键词: LAI microtest;Cell-mediated immunity;Gastric cancer
数据来源: Karger
摘要:
The reactivities of leukocytes from gastric cancer and noncancer patients to gastric tumor and normal tissue extracts were tested by the leukocyte adherence inhibition (LAI) microtest, assessing cell-mediated immunoreactivity to adenocarcinoma of the stomach. The reactivities were expressed with the LAI index. All leukocyte preparations showed low reactivities, a LAI index of less than 20%, to normal tissue extracts and only the preparations of leukocytes from cancer patients displayed high reactivities, a LAI index of more than 20%, to tumor extracts. Assuming that a patient is sensitized to gastric tumor antigen if his leukocytes respond to at least one tumor extract with a LAI index of more than 20%, approximately half of the cancer patients tested in the present study are considered to have positive cell-mediated immunoreactivity to gastric tumor antigen. Thus, the LAI microtest appears to be a simple, rapid and specific method for demonstrating cell-mediated immunity to tumor.
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