Pharmacological activity of a procyanidin isolated fromSclerocarya birreabark: Antidiarrhoeal activity and effects on isolated guinea‐pig ileum
作者:
J. Galvez,
M. E. Crespo,
A. Zarzuelo,
P. De Witte,
C. Spiessens,
期刊:
Phytotherapy Research
(WILEY Available online 1993)
卷期:
Volume 7,
issue 1
页码: 25-28
ISSN:0951-418X
年代: 1993
DOI:10.1002/ptr.2650070108
出版商: John Wiley&Sons, Ltd.
关键词: Sclerocarya birrea;procyanidin;antidiarrhoeal activity
数据来源: WILEY
摘要:
AbstractThe antidiarrhoeal activity of a procyanidin isolated from the bark ofSclerocarya birreawas studied, using four models of experimentally induced diarrhoea in rats. The cathartic agents used were: magnesium sulphate, castor oil, arachidonic acid and prostaglandin E2. At doses of 150 mg/kg, the procyanidin showed antidiarrhoeal activity in all the models of experimentally induced diarrhoea. The procyanidin (2.5 μg/mL‐0.64 mg/mL) dose‐dependently inhibited the phasic contractions of the isolated guinea‐pig ileum spontaneous activity; this inhibition was significantly reduced by hexamethonium (10−4M). It also modified the dose‐response curves to acetylcholine in a non‐competitive way, and relaxed, in a dose‐dependent manner, the contractions induced by acetylcholine (10−7M) and KCI (50 mM), being five times more potent against acetylcholine. The procyanidin modified the biphasic mechanical response evoked by acetylcholine (10−7M) in isolated guinea‐pig ileum, inhibiting the phasic response more profoundly than the tonic one. It is concluded that the antidiarrhoeal activity of the procyanidin isolated fromS. birreabark is related to an inhibition in intestinal motility. The way in which it produces this inhibition can be related to an interference with the subsequent events evoked after mu
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