The role of carotid, aortic and cardiopulmonary receptors and of prostaglandins in the control of renin release was reviewed. It is suggested that the receptors in the low- and high-pressure circuits of the cardiovascular system control renin release through the renal sympathetic nerves and adrenal medulla. It is also suggested that prostaglandins play a role in the control of renin release under certain pathophysiological conditions.