Adolescent substance abuse remains a significant problem confronting the nation. This paper addressed the state of practice with regard to adolescent substance abuse prevention intervention. Data on the extent, nature, and consequences of adolescent substance use are presented and problems with the definition of substance abuse in this population are considered. Primary and secondary prevention programs are discussed, including programs targeting high risk youth, school and peer group, families, and communities. Tertiary prevention intervention efforts are outlines and the need for further treatment research highlighted. In addition, the importance of intervention across multiple populations and systems is emphasized.