Slow increase of homovanillic acid in cerebrospinal fluid after levodopa administration
作者:
C. Raftopoulos,
S. Dethy,
M. A. Laute,
S. Goldman,
A. B. Naini,
S. Przedborski,
J. Hildebrand,
期刊:
Movement Disorders
(WILEY Available online 1996)
卷期:
Volume 11,
issue 1
页码: 59-62
ISSN:0885-3185
年代: 1996
DOI:10.1002/mds.870110111
出版商: Wiley Subscription Services, Inc., A Wiley Company
关键词: Homovanillic acid;Dopamine;Carbidopa;Levodopa;3, 4‐Dihydroxyphenylacetic acid
数据来源: WILEY
摘要:
AbstractConcentrations of major catabolites of dopamine were followed in the ventricular cerebrospinal fluid (CSF) in five patients undergoing intracranial pressure monitoring for chronic hydrocephalus. Determinations were made every 2 h following the administration of carbidopa/levodopa 25/250 mg (one Sinemet capsule) given 8h apart. The rise of homovanillic acid (HVA) concentrations was slow and progressive, reaching the level of statistical significance (p ≤ 0.01) only 8 h after the second administration of Sinemet. The rise in 3,4‐dihydroxy‐phenylacetic acid (DOPAC) was faster than the rise in HVA, with the peak value detected 4 h after the first administration of Sinemet. These data are interpreted as a confirmation, in humans, of a slow pool of exogenous levodopa, previously demonstrated in animal st
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