Responsiveness to endocrine manipulations in breast cancer after “prophylactic” castration
作者:
Richard Kaufman,
Philip Salem,
Robert E. Wittes,
期刊:
Journal of Surgical Oncology
(WILEY Available online 1977)
卷期:
Volume 9,
issue 1
页码: 39-43
ISSN:0022-4790
年代: 1977
DOI:10.1002/jso.2930090107
出版商: Wiley Subscription Services, Inc., A Wiley Company
关键词: breast cancer;prophylactic castration;endocrine therapy
数据来源: WILEY
摘要:
AbstractTwo hundred and one cases of premenopausal women with breast cancer who underwent prophylactic castration with subsequent recurrence were reviewed to ascertain the degree of responsiveness of these patients to subsequent endocrine manipulation. We show that the standard endocrine manipulations, particularly the major ablations, retain a fair degree of activity in this group. There is a suggestion that the longer the castration‐recurrence interval, the higher the chance of a response, but the difference is significant only for osseous‐dominant disease. As in other patient groups, responders to subsequent endocrine manipulations live longer than nonrespond
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