Analysis of Reciprocal Creatinine Plots by Two-Phase Linear Regression
作者:
Peter A. Rowe,
Rosalyn E. Richardson,
Paul R. Burton,
Anthony G. Morgan,
Richard P. Burden,
期刊:
American Journal of Nephrology
(Karger Available online 1989)
卷期:
Volume 9,
issue 1
页码: 38-43
ISSN:0250-8095
年代: 1989
DOI:10.1159/000167932
出版商: S. Karger AG
关键词: Two-phase linear regression;Reciprocal creatinine plots;Chronic progressive renal failure
数据来源: Karger
摘要:
The progression of renal diseases is often monitored by the serial measurement of plasma creatinine. The slope of the linear relation that is frequently found between the reciprocal of creatinine concentration and time delineates the rate of change in renal function. Minor changes in slope, perhaps indicating response to therapeutic intervention, can be difficult to identify and yet be of clinical importance. We describe the application of two-phase linear regression to identify and characterise changes in slope using a microcomputer. The method fits two intersecting lines to the data by computing a least-squares estimate of the position of the slope change and its 95% confidence limits. This avoids the potential bias of fixing the change at a preconceived time corresponding with an alteration in treatment. The program then evaluates the statistical and clinical significance of the slope change and produces a graphical output to aid interpretation.
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