Koker, R. The pharmacokinetic behaviour of chloramphenicol in liver‐damaged mini‐pigs.J. vet. Pharmacol. Therap.8, 82–87.Using mini‐pigs with an indwelling vascular catheter, the pharmacokinetics of chloramphenicol were investigated in healthy and liver‐damaged animals. The liver damage was induced by thioacetamide and its degree was estimated by measuring the level of bile acids in serum. Employing a two‐compartment open model for analysing the time‐dependent course of the chloramphenicol concentration in serum, it was shown that in liver‐damaged animals the elimination half‐time was almost doubled as a result of reduced total body clearance. The consequences of liver damage for withdrawal limes and dosage schedules are discussed.R. Kroker, Federal Health Office. Institute for Veterinary Medicine, 1000 B