Mitogenic responses of peripheral blood mononuclear cells of vervet monkeys(Cercopithecus aethiops):Apparent role of adherent cells
作者:
Joseph O. Olobo,
Graham D. F. Reid,
期刊:
American Journal of Primatology
(WILEY Available online 1990)
卷期:
Volume 20,
issue 1
页码: 31-36
ISSN:0275-2565
年代: 1990
DOI:10.1002/ajp.1350200105
出版商: Wiley Subscription Services, Inc., A Wiley Company
关键词: mitogens;blastogenic responses;lymphocytes
数据来源: WILEY
摘要:
AbstractPeripheral blood mononuclear cells (PBM) from normal vervet monkeys(Cercopithecus aethiops)were examined for blastogenic responses to concanavalin A (ConA), phytohemagglutinin (PHA), and pokeweed mitogen (PWM). The mitogen stimulated PBM in a dose‐dependent manner. Response to ConA was apparently higher than for the other two mitogens. Cell density and mitogen concentration were critical parameters for optimal lymphocyte proliferation, an observation in line with that reported for other mammalian species. Depletion of an adherent cell population probably of monocyte/macrophage lineage from vervet PBM gave higher proliferative responses to both ConA and PHA, but the response without adherent cells to ConA was greater than the response without adherent cells to PHA. This latter finding is in contrast to what has been reported in many other specie
点击下载:
PDF
(399KB)
返 回