Hyperglycemia and glycosuria are known to occur in pediatric patients diagnosed with acute lymphocytic leukemia and treated with L-asparaginase and prednisone for induction therapy. Although these complications are uncommon, they can have a major impact on the treatment of the patient. Nurses providing care for these patients have a vital role in the detection, management, and education of the patient and family. This article provides current information on etiology, risk factors, and patient management of drug-induced diabetes for pediatric patients with leukemia. Early diagnosis, management, and extensive education promote control of this secondary disease and prevent further complications.