Depression of lymphocyte replicating ability in radiotherapy patients
作者:
期刊:
The British Journal of Radiology
(WILEY Available online 1974)
卷期:
Volume 47,
issue 553
页码: 37-43
年代: 1974
DOI:10.1259/0007-1285-47-553-37
出版商: The British Institute of Radiology
数据来源: WILEY
摘要:
AbstractThe effects of radiation upon circulating lymphocytes have been measured by two independent means, one monitoring the level of cytogenetic damage appearing in these cells, the other monitoring changes in their proliferative response to stimulation in culture by phytohaemagglutin (PHA). Response to PHA can be expressed quantitatively as lymphocyte replicating ability (LRA),i.e.the degree of3H-thymidine uptake measured under standardized conditions. Varying degrees of depression of LRA have been noted within a group of patients undergoing a wide range of radiotherapeutic procedures. The concomitant cytogenetic studies indicate that although cells bearing radiation damage do persist in the circulation after irradiation their numbers are insufficient to account for the marked reduction seen at the same time in LRA. It appears that the reduction is largely due to a fall in the number of thymusdependent lymphocytes in the circulatory pool.
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