首页   按字顺浏览 期刊浏览 卷期浏览 Increased Low‐Density Lipoprotein Levels After SplenectomyA Role for the Spleen ...
Increased Low‐Density Lipoprotein Levels After SplenectomyA Role for the Spleen in Cholesterol Metabolism in Myeloproliferative Disorders

 

作者: M. AVIRAM,   J. BROOK,   I. TATARSKY,   Y. LEVY,   A. CARTER,  

 

期刊: The American Journal of the Medical Sciences  (OVID Available online 1986)
卷期: Volume 291, issue 1  

页码: 25-28

 

ISSN:0002-9629

 

年代: 1986

 

出版商: OVID

 

关键词: Lipoproteins;Low-density lipoprotein (LDL);Myeloproliferative disease;Spleen

 

数据来源: OVID

 

摘要:

Patients with myeloproliferative disorders demonstrate decreased plasma cholesterol and apolipoprotein B concentrations, and this has been related to the presence of a large spleen. Patients that underwent splenectomy in the past demonstrated normal plasma cholesterol levels. Plasma high-density lipoprotein (HDL) cholesterol and apolipoprotein A-I were also reduced in these patients, but were normal after splenectomy. To study the immediate effect of splenectomy on the plasma lipid pattern, three patients with myeloproliferative disease and a large spleen who were undergoing splenectomy were compared with two control groups, one undergoing orthopedic operations and the second, cholecystectomy. In the control groups, plasma lipids tended to decrease for the first 2 days after surgery and then returned to preoperative levels. After splenectomy, however, plasma cholesterol, low-density lipoprotein (LDL), and apolipoprotein B significantly increased, reaching maximum levels after 4 days. Plasma HDL as well as apolipoprotein A-I decreased 1 day after splenectomy, but then increased over and above their preoperative concentrations. These results suggest an important role for the spleen in cholesterol metabolism in these patients. The spleen appears to be an important site for LDL catabolism in these patients.

 

点击下载:  PDF (326KB)



返 回