Myoglobinuria Exacerbates Ischemic Renal Damage in the Dog
作者:
Anil K. Mandal,
John B. Davis, Jr.,
Richard D. Bell,
Jon M. Miller,
期刊:
Nephron
(Karger Available online 1989)
卷期:
Volume 53,
issue 3
页码: 261-267
ISSN:1660-8151
年代: 1989
DOI:10.1159/000185755
出版商: S. Karger AG
关键词: Acute renal failure;Glycerol model;Renal ischemia;Potentiating factors
数据来源: Karger
摘要:
The effects of intramuscular glycerol on ischemic acute renal failure was investigated in dogs. Anesthetized dogs received a bilateral 120-min renal artery obstruction (RAO) alone, RAO plus 5 ml/kg of 50% glycerol or RAO plus 5 ml/kg of 75% glycerol. Control groups received the glycerol injection, but not RAO. Renal histopathology was minimal in dogs receiving glycerol alone. In RAO dogs, those receiving 50% glycerol showed diffuse acute tubular necrosis (ATN), while those receiving 75% glycerol had severe ATN with extreme mortality. Changes in serum creatinine, creatinine clearance, and fractional excretion of sodium were consistent with the histopathologic changes. We conclude that myoglobinuria, of a degree insufficient to cause renal failure itself, can interact with renal ischemia to significantly exacerbate the renal damage produced.
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