Propolis allergy (IV) Studies with further sensitizers from propolis and constituents common to propolis, poplar buds and balsam of Peru
作者:
B. M. Hausen,
P. Evers,
H ‐T. Stüwe,
W. A. König,
E. Wollenweber,
期刊:
Contact Dermatitis
(WILEY Available online 1992)
卷期:
Volume 26,
issue 1
页码: 34-44
ISSN:0105-1873
年代: 1992
DOI:10.1111/j.1600-0536.1992.tb00865.x
出版商: Blackwell Publishing Ltd
关键词: propolis: poplar bud exudates;balsam of Peru;phenolic constituents: guinea pig sensitization;caffeates;cinnamates: (iso‐)ferulates;benzoates: coniferyl benzoute
数据来源: WILEY
摘要:
26 different compounds have been investigated experimentally for their sensitizing capacity in guinea pigs. 19 of these occur in propolis as well as in poplar bud exudates, and 14 of them are also found in balsam of Peru. 4 caffeates and benzyl isoferulate were found to be strong Sensitizers. 7 compounds were moderate, and 13 compounds showed only weak sensitizing potency. Methyl cinnamate was negative. Patch tests in 11 propolis‐sensitive patients once more revealed 3‐methyi‐2‐butenyl caffeate and phenylethyl caffeate as the major sensitizers. In addition to the 8 compounds already known to occur in propolis as well as in balsam of Peru, we detected 5 further substances that both materials have in common. Among these, benzyl isoferulate is considered a noteworthy sensitizer. Coniferyl benzoate, which was shown to be a moderate sensitizer, is present in fresh samples of balsam of Peru, while in propolis it has been detected only once so far. The flavonoid aglycones occurring in poplar bud exudates, and hence also in propolis, are weak sensitizers which play only a minor role m propolis hypersens
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