Role of salivary mucins in the protection of the oral cavity
作者:
Lawrence A. Tabak,
Michael J. Levine,
Irwin D. Mandel,
Solon A. Ellison,
期刊:
Journal of Oral Pathology&Medicine
(WILEY Available online 1982)
卷期:
Volume 11,
issue 1
页码: 1-17
ISSN:0904-2512
年代: 1982
DOI:10.1111/j.1600-0714.1982.tb00138.x
出版商: Blackwell Publishing Ltd
数据来源: WILEY
摘要:
Mucins are the principal organic constituents of mucus, the slimy visco‐elastic material that coats all mucosal surfaces. Compelling evidence suggests that they play an integral role in non‐immune protection of the oral cavity. Specific protective functions include: 1) protection against desiccation and environmental insult, 2) lubrication, and 3) antimicrobial effects against potential pathogens. Biosynthesis of mucin is regulated by both intrinsic (“cooperative sequential specificity”) and extrinsic (“structural modulation”) controls. These controls form the basis by which mucin's structure can be modified to meet a dynamically changing biol
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