The Age‐Related Incidence of Meconium Ileus Equivalent in a Cystic Fibrosis PopulationThe Impact of High‐Energy Intake
作者:
Henrik,
&phis;rbaek Andersen Karsten,
Hjelt Elisabeth,
Waever Karsten,
期刊:
Journal of Pediatric Gastroenterology and Nutrition
(OVID Available online 1990)
卷期:
Volume 11,
issue 3
页码: 356-360
ISSN:0277-2116
年代: 1990
出版商: OVID
关键词: Meconium ileus equivalent;Incidence;Cystic fibrosis;Diet;Exocrine pancreas enzyme supplementation
数据来源: OVID
摘要:
During the decade from 1976 to 1986, the age-related incidence of meconium ileus equivalent (MIE) was calculated on the basis of 240 Danish cystic fibrosis (CF) patients. In the first 5 years, the patients were given enteric-coated granules of pancreatic enzymes (Pancreatin, Rosco, Denmark), and a low fat diet was recommended. In the last 5 years, the Center recommended supplementation with acid-resistent, enteric-coated, encapsulated microspheres (Pancrease, Cilag, Birker&phis;d, Denmark), and high-energy intake with a 40% fat content and no dietary restrictions. There was no difference in the incidence of MIE when these two 5-year periods were compared, and the overall incidence of MIE was low (5.4 MIEs/1.000 patient years). This may, at least in part, be due to the rather high intake of exocrine pancreas enzyme supplementation (EPES) (a mean intake of 0.9 capsules/kg/day). MIE occurred almost exclusively among patients >15 years old and peaked in young adults aged 20–25 years (35.5 MIEs/1.000 patient years). The daily intake of EPES/kg of body weight declined significantly with age, and the patients who developed MIE received even less than average per day. Both of these points strengthen the view that a low enzyme dosage is likely to have an effect on the incidence of MIE.
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