Diabetes mellitus in Kearns-Sayre Syndrome
作者:
Yuzo Tanabe,
Shigeki Miyamoto,
Yoshihiko Kinoshita,
Kazutaka Yamada,
Nozomu Sasaki,
Eiichi Makino,
Hironori Nakajima,
期刊:
European Neurology
(Karger Available online 1988)
卷期:
Volume 28,
issue 1
页码: 34-38
ISSN:0014-3022
年代: 1988
DOI:10.1159/000116225
出版商: S. Karger AG
关键词: Kearns-Sayre syndrome;Diabetes mellitus;Mitochondrial myopathy
数据来源: Karger
摘要:
A 20-year-old woman with Kearns-Sayre syndrome (KSS) suddenly experienced two episodes of diabetic coma. She was studied to determine whether diabetes mellitus (DM) resulted from insulin resistance or from an insulin secretion abnormality, using the euglycemic glucose clamp technique and the glucagon tolerance test. She had a deficiency of insulin secretion from beta cells. It is important to recognize in practice the onset of DM in patients with mitochondrial myopathy. We would suggest that a genetic linkage or mitochondrial dysfunction may be responsible for the association of both disease states.
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