The effect of nutritional support on T-lymphocyte subpopulations in protein calorie malnutrition.
作者:
AbbottW C,
TayekJ A,
BistrianB R,
MakiT,
AinsleyB M,
ReidL A,
BlackburnG L,
期刊:
Journal of the American College of Nutrition
(Taylor Available online 1986)
卷期:
Volume 5,
issue 6
页码: 577-584
ISSN:0731-5724
年代: 1986
DOI:10.1080/07315724.1986.10720158
出版商: Routledge
数据来源: Taylor
摘要:
T-lymphocyte subpopulations were measured in the two major types of adult malnutrition, adult marasmus and kwashiorkor-like hypoalbuminemic malnutrition. The population of T-cells (T3) and the percentage of both helper (T4) and suppressor (T8) T-cells were significantly (P less than .05) decreased in patients with kwashiorkor-like hypoalbuminemic malnutrition, but did not differ from control values in patients with adult marasmus. The ratio of helper T-cell (T4), to suppressor T-cells (T8) (range 1.2-1.6) did not vary from control values in either type of malnutrition. One week of nutritional support was not associated with a significant increase in any of the T lymphocyte subpopulations in either type of malnutrition. These T-cell subpopulation changes are consistent with the greater depression of cellular immune function seen in patients with metabolic stresses associated with kwashiorkor-like hypoalbuminemic malnutrition. With the increasing frequency in which abnormalities of T-cell subpopulations are being reported in various diseases, the coexistence of kwashiorkor-like hypoalbuminemic malnutrition should be noted for its potentially confounding effect.
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