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An Experimental Model for Evaluation of Antifungal Agents in aTrichophyton mentagrophytesInfection of Guinea Pigs

 

作者: Mary E. Valiant,   Bettina M. Frost,  

 

期刊: Chemotherapy  （Karger Available online 1984）
卷期: Volume 30, issue 1  

页码: 54-60

 

ISSN:0009-3157

 

年代: 1984

 

DOI:10.1159/000238246

 

出版商: S. Karger AG

 

关键词: Trichophyton mentagrophytes;Clotrimazole;Miconazole;Tolnaftate;Griseofulvin;Ketoconazole;In vivo efficacy

 

数据来源: Karger

 

摘要:

A Trichophyton mentagrophytes infection of guinea pigs induced by an occlusive procedure is described. The method of evaluation permits comparison of efficacy of antifungal agents which are not tested simultaneously. Activity was demonstrated following topical application of clotrimazole, miconazole, tolnaftate or griseofulvin and oral administration of griseofulvin. Oral ketoconazole had little effect in this dermatophyte model.

 

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