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Comparison of 5-Fluorouracil, Doxorubicin and Mitomycin C with 5-Fluorouracil Alone in the Treatment of Pancreatic-Biliary Carcinomas

 

作者: Tadahiro Takada,   Hiroyuki Kato,   Takashi Matsushiro,   Yuji Nimura,   Takukazu Nagakawa,   Toshimichi Nakayama,  

 

期刊: Oncology  （Karger Available online 1994）
卷期: Volume 51, issue 5  

页码: 396-400

 

ISSN:0030-2414

 

年代: 1994

 

DOI:10.1159/000227373

 

出版商: S. Karger AG

 

关键词: Pancreatic carcinoma;Biliary tract carcinoma;Chemotherapy;combination

 

数据来源: Karger

 

摘要:

In this multicenter randomized trial, the efficacy of combination chemotherapy using 5-fluorouracil, doxorubicin and mitomycin C (arm A) was compared with that of 5-fluorouracil alone (arm B) in 81 patients with nonresectable carcinomas of the pancreas or biliary tract. There were no significant differences between treatment arms regarding the median time to progressive disease, median survival time, palliative effects or toxicities. It was concluded that combination chemotherapy is feasible but cannot be recommended.

 

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