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35S-Thiophosphonsäure, ein mögliches Radiotherapeutikum bei der Behandlung von Knochenmetastasen – Synthese und Bioverteilung

 

作者: W. Finck,   S. Unterspann,   B. Hoffmann,   B. Costisella,   H. Groβ,   S. Tustanowski,  

 

期刊: Isotopenpraxis Isotopes in Environmental and Health Studies  （Taylor Available online 1987）
卷期: Volume 23, issue 4  

页码: 125-128

 

ISSN:0021-1915

 

年代: 1987

 

DOI:10.1080/10256018708623772

 

出版商: Taylor & Francis Group

 

关键词: biochemical reaction kinetics;bone marrow;labelling;metastases;nuclear medicine;phosphonic acid esters;radio-pharmaceuticals;skeletal diseases;sulfur 35

 

数据来源: Taylor

 

摘要:

99mTc labelled diphoxphonic acids are worldwide used in diagnostic of sheletal diseases. We have tryed to utilize the high accumulation in the areas with increased bone metabolism for therapy. Bone marrow radiation sensitivity limits the application dose. A low energy β−-emitter will not penetrate the total marrow areas. A synthesis had been developed for preparation a35-thiophosphonic acid. The accumulation ratio up to 1:10 (normal to damaged bone), the distance distribution of bone marrow structures surrounding the marrow areas and the maximum range of35S-β−-parlicles give the chance for a therapeutic concept.

 

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