This article reviews advances over the past year in our understanding of the regulation of gastric pepsinogen secretion. These advances are placed in the context of previous observations regarding signal transduction in chief cells. The actions of stimulatory agents,ie, cholinergic agonists, cholecystokinin, secretin, vasoactive intestinal polypeptide and so on are described. Advances in understanding interactions between signaling pathways and the actions of inhibitory peptides, like peptide YY and neuropeptide Y, are also considered. The review concludes with an analysis of where investigation in this field appears to be directed at present.