Combined Inhibition Effects of Tacrolimus and Methylprednisolone on in Vitro Human Lymphocyte Proliferation
作者:
JeongMi,
PyszczynskiNancy,
JuskoWilliam J.,
期刊:
Immunopharmacology and Immunotoxicology
(Taylor Available online 1995)
卷期:
Volume 17,
issue 2
页码: 335-345
ISSN:0892-3973
年代: 1995
DOI:10.3109/08923979509019755
出版商: Taylor&Francis
数据来源: Taylor
摘要:
AbstractTacrolimus (FK 506) has synergistic immunosuppressive effects in combination with corticosteroids. A steroid dose-lowering effect can be explained partly by the inhibition by FK 506 of cytochrome P-450 III A, which metabolizes corticosteroids. We investigated the influence of combinations of FK 506 and methylprednisolone (MPL) on the suppression of in vitro human lymphocyte proliferation. to quantify the type of drug interaction (synergistic, additive, and antagonistic), three methods (Drewinko's statistical analysis, median-effect principle, and normal distribution model) were used. the interaction appeared synergistic in most combination ratios, but the extent of synergism varied depending on the quantitative method. There may be optimal combination ratios of FK 506 and MPL which achieve more effective immunosuppressive effects.
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