A new application of in situ hybridization: detection of numerical and structural chromosome aberrations with a combination centromeric-telomeric DNA probe
作者:
H. van Dekken,
J.G.J. Bauman,
期刊:
Cytogenetic and Genome Research
(Karger Available online 1988)
卷期:
Volume 48,
issue 3
页码: 188-189
ISSN:1424-8581
年代: 1988
DOI:10.1159/000132622
出版商: S. Karger AG
数据来源: Karger
摘要:
Fluorescent in situ hybridization provides a fast method for detection of specific nucleic acid sequences. We have used high-resolution, single-color fluorescent in situ hybridization with a combination centromeric-telomeric DNA probe, specific for chromosome 1, to investigate the feasibility of simultaneous assessment of numerical and structural chromosome aberrations. The K562 leukemia cell line served as a model.
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