Störung zellvermittelter Immunreaktionen bei Neurodermitis atopica
作者:
Erwin Schöpf,
期刊:
Dermatology
(Karger Available online 1974)
卷期:
Volume 149,
issue 4
页码: 210-219
ISSN:1018-8665
年代: 1974
DOI:10.1159/000251522
出版商: S. Karger AG
关键词: Atopic dermatitis;Rosette-forming T cells
数据来源: Karger
摘要:
In 17 patients with atopic dermatitis and in 17 healthy control persons, rosette-forming T cells from peripheral blood were investigated. The percentage of rosette-forming T cells in atopies was significantly lower (p < 0.0025) than in the control group. In patients with atopic dermatitis there was a significant correlation between IgE serum levels and the number of rosette-forming T cells. Increase in IgE level is correlated to a decrease in the number of rosette-forming T cells. It is suggested that the primary defect in the immunological system in atopies may be found in the thymus- or T-cell-mediated immunological system, and that this defect be characterized by a decrease or lack of T cells with suppressor function for IgE formation.
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