Spontaneously Acquired Factor VIII Inhibitor in a 7-Year-Old Girl
作者:
Koji Nakashima,
Taeko Miyahara,
Shinya Fujii,
Kohei Kaku,
Noboru Matsumoto,
Toshio Kaneko,
期刊:
Acta Haematologica
(Karger Available online 1982)
卷期:
Volume 68,
issue 1
页码: 58-62
ISSN:0001-5792
年代: 1982
DOI:10.1159/000206949
出版商: S. Karger AG
关键词: Cyclophosphamide;Immunosuppression;Inhibitor of factor VIII
数据来源: Karger
摘要:
The youngest case with spontaneously acquired inhibitor to factor VIII is reported. A 7-year-old girl without any previous disorders presented with a hemarthrosis in the left knee and developed a rapidly expanding hematoma on the right arm, shoulder and chest after an initial infusion of factor VIII concentrate (1,000 units). Circulating anti-factor VIII antibody was detected. Her coagulopathy was successfully managed with an additional massive infusion of factor VIII concentrate (7,500 units) and combination therapy of prednisolone and cyclophosphamide.
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