IsPia Selectively Balanced Polymorphism?
作者:
N.G. Martin,
J.G. Oakeshott,
期刊:
Human Heredity
(Karger Available online 1983)
卷期:
Volume 33,
issue 1
页码: 24-28
ISSN:0001-5652
年代: 1983
DOI:10.1159/000153342
出版商: S. Karger AG
关键词: α1-Antitrypsin;Pisubtypes;Serum levels;Balanced polymorphism
数据来源: Karger
摘要:
A stable polymorphism of the Pi alleles M1, M2 and M3 close to their observed frequencies has been predicted, simply by relating fitness to the proportion of each genotype having α1-antitrypsin (α1-AT) levels greater than 100 mg/100 ml. By further specifying that the rare S and Z genotypes with low α1-AT levels have enhanced fertility, equilibria of the M, S and Z alleles have also been predicted close to their observed frequencies; however, none of these latter equilibria is stable, mainly because the predicted fitness of the SS genotype is too gre
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