Plasma Cyclic Nucleotide Responses to Methacholine and Epinephrine in Patients With Migraine
作者:
Fumihiko Okada,
Tsutomu Miyagishi,
Miyuki Honma,
Michio Ui,
期刊:
Headache: The Journal of Head and Face Pain
(WILEY Available online 1984)
卷期:
Volume 24,
issue 1
页码: 26-29
ISSN:0017-8748
年代: 1984
DOI:10.1111/j.1526-4610.1984.hed2401026.x
出版商: Blackwell Science Inc
数据来源: WILEY
摘要:
SYNOPSISThe purpose of the present study is to show anomalies of the plasma cyclic nucleotide responses of patients with migraine to intramuscular injections of methacholine (80 μg/kg body wt) and epinephrine (0.4 mg/person). The methacholine‐ or epinephrine‐induced increases in plasma cyclic GMP were much larger in patients with migraine than in controls. In the case of methacholine injection, there was also a small but significant rise of plasma cyclic AMP in patients with migraine, while no change was observed in controls. On the other hand, there was no significant difference in the epinephrine‐induced increase in plasma cyclic AMP between patients with migraine and controls. From these findings it may be assumed that cholinergic or a‐adrenergic receptor responses are enhanced in patients with
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