Hippocampal Variation between the Inbred Mouse Strains C3H/HeJ and DBA/2: A Quantitative-genetic Analysis
作者:
HeimlichB.,
SchweglerH.,
CrusioW. E.,
期刊:
Journal of Neurogenetics
(Taylor Available online 1985)
卷期:
Volume 2,
issue 6
页码: 389-401
ISSN:0167-7063
年代: 1985
DOI:10.3109/01677068509101425
出版商: Taylor&Francis
关键词: hippocampus;two-way avoidance;mouse;quantitative genetics;classical cross
数据来源: Taylor
摘要:
A classical cross-breeding study involving the inbred mouse strains DBA/2 and C3H/HeJ revealed a rather complex mode of inheritance for the following hippocampal variables: size of stratum pyramidale, number of supra-, intra- and infrapyramidal mossy fiber synapses, and the size of terminal fields receiving entorhinal input. A polygenic mode of inheritance was inferred for these phenotypes. For the size of the regio inferior a model containing additive genetic effects only was sufficient to explain the variation between generations. The strain difference may be caused by one genetic factor only. In agreement with previous experiments a strong negative correlation between the number of intra- and infrapyramidal mossy fiber synapses and shuttle-box avoidance performance was found in the genetically heterogeneous F2population.
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