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Designing of Peptide Substrates

 

作者: Göran Claeson,   Leif Aurell,   Petter Friberger,   Stig Gustavsson,   Gunilla Karlsson,  

 

期刊: Pathophysiology of Haemostasis and Thrombosis  （Karger Available online 1978）
卷期: Volume 7, issue 2-3  

页码: 62-68

 

ISSN:1424-8832

 

年代: 1978

 

DOI:10.1159/000214236

 

出版商: S. Karger AG

 

关键词: Chromogenic substrate;Synthesis;Kallikrein;Urokinase;Enzymatic cleavage

 

数据来源: Karger

 

摘要:

Chromogenic peptide substrates for serine proteases have been designed by using two approaches: (1) by using the natural substrate as a model and (2) by structure-activity correlations obtained through screening of a large number of tripeptides. Some recent examples, substrates for kallikreins and urokinase are given.

 

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