Absence of Relationships between L-Dopa Plasma Levels and Therapeutic Effect in Parkinson’s Disease Treated with L-Dopa
作者:
S. Algeri,
S. Ruggieri,
F. Miranda,
M. Casacchia,
P.L. Morselli,
A. Agnoli,
期刊:
European Neurology
(Karger Available online 1976)
卷期:
Volume 14,
issue 3
页码: 219-228
ISSN:0014-3022
年代: 1976
DOI:10.1159/000114743
出版商: S. Karger AG
关键词: L-Dopa;L-Dopa level;Parkinson’s disease
数据来源: Karger
摘要:
The plasma concentration of dopa was studied in 15 parkinsonian patients after a single administration of L-dopa. The study was undertaken in order to determine if correlation between plasma dopa concentration and clinical performance as a result of the tests carried out before and after a single dose of dopa, was present. Our data confirm the absolute absence of correlation between dopa levels in plasma and clinical improvement during long-term treatment. Moreover, clinical responses to the performance tests were not related to the concentration of circulating L-dopa in the plasma. Therefore dopa levels cannot be useful in clinical practice but only for the prevention of too high concentrations of plasma L-dopa which often cause a few side-effects.
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