Effect of Changing Medication Regimens in Glaucoma Patients
作者:
Gary D. Novack,
Robert David,
Pei-Fei Lee,
Melvin I. Freeman,
Efraim Duzman,
Amy L. Batoosingh,
期刊:
Ophthalmologica
(Karger Available online 1988)
卷期:
Volume 196,
issue 1
页码: 23-28
ISSN:0030-3755
年代: 1988
DOI:10.1159/000309870
出版商: S. Karger AG
关键词: Glaucoma;Compliance;Levobunolol;Timolol;Intraocular pressure
数据来源: Karger
摘要:
When glaucoma medication fails to adequately control intraocular pressure (IOP), a second medication is frequently added. Before adding a second drug to patients whose IOP was no longer controlled by 0.5% timolol, we tested the effect of switching to another beta blocker, levobunolol (0.5 or 1%). We also evaluated the effect of study participation on compliance in the control group continuing to receive 0.5% timolol. In each treatment group, the IOP of approximately 30–40% of the patients was successfully controlled for the 3-month study period. The remaining patients did not exhibit significant pressure reductions and were dropped from the study within 2 weeks. We concluded that (1) the results of’switch’ studies without a control group must be interpreted carefully, and (2) the initiation of a ‘new regimen’ with an equieffective beta blocker may be sufficient to increase compliance and thereby control IOP.
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