Effects of Dextran and Crystalloids on Subcutaneous Oxygen Tension and Collagen Accumulation
作者:
M. Hartmann,
K. Jönsson,
B. Zederfeldt,
期刊:
European Surgical Research
(Karger Available online 1993)
卷期:
Volume 25,
issue 5
页码: 270-277
ISSN:0014-312X
年代: 1993
DOI:10.1159/000129289
出版商: S. Karger AG
关键词: Wound healing;Collagen;Hydroxyproline;Tissue oxygen tension;Tissue perfusion;Rehydration;Crystalloid;Dextran 70
数据来源: Karger
摘要:
Twenty-nine patients, subjected to major abdominal surgery, were randomized to different types of postoperative fluid replacement, given on the basis of subcutaneous oxygen tension measurements (PscO2). One regimen consisted of crystalloids, the other of a combination of crystalloids and colloids (dextran 70). Perioperative fluid replacement was given according to clinical criteria and postoperatively according to polarographic PscO2 measurements. PscO2 was measured by a silicone catheter implanted in the upper arm. Two tubes of expanded polytetrafluoroethylene (ePTFE) were implanted next to the silicon catheter. They were removed on day 5 and 7, and analysed for hydroxyproline content. Total postoperative fluid support was equal in the two groups, and so was the hydroxyproline content on day 7. In conclusion, postoperative fluid substitution with dextran has no advantages over crystalloids only, with regard to granulation tissue formation if postoperative fluid support is optimum, according to PscO2 measurements.
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