Clofibrate-Induced Myotoxicity in Rats
作者:
A.K. Afifi,
G.A. Hajj,
S. Saad,
A. Tekian,
R.A. Bergman,
N.B. Bahuth,
N. Abourizk,
期刊:
European Neurology
(Karger Available online 1984)
卷期:
Volume 23,
issue 3
页码: 182-197
ISSN:0014-3022
年代: 1984
DOI:10.1159/000115701
出版商: S. Karger AG
关键词: Clofibrate;Clofibrate myopathy;Clofibrate neuropathy;Clofibrate muscular atrophy
数据来源: Karger
摘要:
In this report, the temporal sequence of myopathology during a clofibrate-induced muscular syndrome and its recovery in rats is described using histopathologic, histochemical and electron microscopic technics. Two stages of myopathology are described: an early stage characterized by myopathic features, and a later stage characterized by neurogenic features. Although muscle histology returns to normal after 1 week of discontinuing the drug, electron microscopic abnormalities persist through the second week. It is proposed that clofibrate, in addition to its myotoxic effect, may be neurotoxic.
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