Pseudoxanthoma-elasticum-Like Skin Changes Induced by Penicillamine
作者:
J.L. Bolognia,
I. Braverman,
期刊:
Dermatology
(Karger Available online 1992)
卷期:
Volume 184,
issue 1
页码: 12-18
ISSN:1018-8665
年代: 1992
DOI:10.1159/000247491
出版商: S. Karger AG
关键词: Pseudoxanthoma elasticum;Penicillamine;Elastic fibers
数据来源: Karger
摘要:
The interference of penicillamine with collagen and elastin cross-linking can lead to wrinkling and anetoderma-like lesions in flexural areas as well as fragility and hemorrhagic blisters in pressure areas. These changes are seen primarily in patients with Wilson’s disease or cystinuria who are on long-term therapy. This is a report of a patient with cystinuria on long-term, high-dose penicillamine who developed pseudoxanthoma-elasticum-like lesions. Coalescent yellow papules with a ‘plucked-chicken skin’ appearance were seen in the axillae and on the neck while redundant skin folds were noted in the anterior axillary line and lower buttocks. By light and electron microscopy, involved and uninvolved skin demonstrated ‘lumpy-bumpy’ dermal elastic fibers with no calcium deposition. These histologic changes are similar to those previously described in patients with penicillamine-induced ski
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