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Attempted Prevention of Blast Crisis in Chronic Myeloid Leukemia by the Use of Pulsed Doses of Cytosine Arabinoside and cis-Chloronitrosurea During the Course of Busulfan-Maintained Remission

 

作者: SilverRichard T.,   MickRosemarie,   DegnanThomas J.,   HollandJames F.,   CavelliFranco,  

 

期刊: Cancer Investigation  （Taylor Available online 1988）
卷期: Volume 6, issue 3  

页码: 255-262

 

ISSN:0735-7907

 

年代: 1988

 

DOI:10.3109/07357908809080646

 

出版商: Taylor&Francis

 

数据来源: Taylor

 

摘要:

AbstractWe performed this chemotherapeutic trial to try to delay the onset of the blast crisis of chronic myeloid leukemia (CML) by pulsing doses of drugs most likely to be effective against emerging“blast”cells characteristic of acute phase disease. A randomized trial in patients with CML comparing busulfan maintenance to busul-fan maintenance plus pulsed doses of cytarabine and lomustine did not yield any differences in either time to blast crisis or death.

 

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