A fatal spongiform encephalopathy of sheep and goats (scrapie) shares many characteristics with Creutzfeldt-Jakob disease (CJD), a similar dementing illness of humans. To investigate the possibility that CJD is acquired by ingestion of contaminated sheep products, we collected information on production, slaughtering practices, and marketing of sheep in Pennsylvania. The study revealed that (1) sheep were usually marketed before central nervous system signs of scrapie are expected to appear; (2) breeds known to be susceptible to the disease were the most common breeds raised in the area; (3) sheep were imported from other states including those with a high frequency of scrapie; (4) use of veterinary services on the sheep farms investigated and, hence, opportunities to detect the disease were limited; (5) sheep producers in the area knew little about scrapie despite the fact that the disease has been reported in the area, and (6) animal organs including sheep organs were sometimes included in processed food. Therefore, it was concluded that in Pennsylvania there are some ''weak links'' through which scrapie-infected animals could contaminate human food, and that consumption of these foods could perhaps account for spongiform encephalopathy in humans. The weak links observed are probably not unique to Pennsylvania.