Local lnterleukin-2 Therapy for Cancer, and Its Effector Induction Mechanisms
作者:
Saburo Sone,
Takeshi Ogura,
期刊:
Oncology
(Karger Available online 1994)
卷期:
Volume 51,
issue 2
页码: 170-176
ISSN:0030-2414
年代: 1994
DOI:10.1159/000227331
出版商: S. Karger AG
关键词: IL-2;Malignant pleuritis;Local immunotherapy;Killer induction
数据来源: Karger
摘要:
This paper reviews the effectiveness of local interleukin-2 (IL-2) therapy and its effector induction mechanisms in vivo. Local therapy with IL-2 and/or lymphokine-activated killer (LAK) cells is associated with far fewer side effects than systemic treatment. Local infusions of IL-2 into malignant pleural effusions and the peritoneal cavity induce LAK cells and secondary production of other cytokines responsible for up- or down-regulation of LAK activity. An understanding of the regulatory mechanism of local LAK induction in vivo may provide the rationale for a more effective therapeutic modality for cancer in humans.
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