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Effects of Lonidamine on Murine and Human Tumor Cells in vitro

 

作者: C.D. De Martinet,   T. Battelli,   M.G. Paggi,   A. Nista,   M.L. Marcante,   S. D’Atri,   W. Malorni,   M. Gallo,   A. Floridi,  

 

期刊: Oncology  （Karger Available online 1984）
卷期: Volume 41, issue 1  

页码: 15-29

 

ISSN:0030-2414

 

年代: 1984

 

DOI:10.1159/000225881

 

出版商: S. Karger AG

 

关键词: Lonidamine;Murine and human tumor cells;Mitochondria;Ultrastructural changes;Glycolysis;Pentose phosphate pathway;Aromatase

 

数据来源: Karger

 

摘要:

Lonidamine induces in murine and human tumor cells severe morphological damage of the mitochondria and other cytoplasmic structures both ‘in vitro’ and ‘in vivo’. Biochemical studies have demonstrated that the drug decreases oxygen consumption and lactate production. The sensitivity of human tumor cells is not related to their histotype. Lonidamine’s effects on mitochondria, glycolysis, pentose phosphate pathway, and aromatase activity are

 

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