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Biochemical Changes in Human Cervical Connective Tissue after Local Application of Prostaglandin E2

 

作者: Niels Uldbjerg,   Gunvor Ekman,   Anders Malmström,   Ulf Ulmsten,   Lars Wingerup,  

 

期刊: Gynecologic and Obstetric Investigation  （Karger Available online 1983）
卷期: Volume 15, issue 5  

页码: 291-299

 

ISSN:0378-7346

 

年代: 1983

 

DOI:10.1159/000299423

 

出版商: S. Karger AG

 

关键词: Uterine cervix;PGE2;Glycosaminoglycans;Collagen;Collagenase

 

数据来源: Karger

 

摘要:

Intracervical application of prostaglandin E2 in the late first trimester induces (1) softening of the cervix tissue; (2) increase in sulfated glycosaminoglycans (18 ± 12%, mean ± SEM): (3) no change in hyaluronic acid and water; (4) decrease in pepsin-extractable collagen, and (5) apparent decrease in collagenase. A high activity of collagenase in combination with a replacement of collagen with sulfated glycosaminoglycans may be of importance for the ripening process.

 

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