Tamoxifen and Natural Progesterone as Supplements to Low-Dose Postmenopausal Estrogen Therapy
作者:
Antti Kauppila,
Seppo Kivinen,
Freij Stenbäck,
Reijo Vihko,
Salme Vuopala,
期刊:
Gynecologic and Obstetric Investigation
(Karger Available online 1988)
卷期:
Volume 25,
issue 1
页码: 58-65
ISSN:0378-7346
年代: 1988
DOI:10.1159/000293746
出版商: S. Karger AG
关键词: Antiestrogen;Natural progesterone;Estrone sulfate;Climacterium;Human endometrium;Lipid metabolism;Anterior pituitary hormones;Ovarian hormones
数据来源: Karger
摘要:
Postmenopausal women received 1 mg estrone sulfate a day for 3 weeks in 12 sequences separated by a 7-day interval without medication and every second time by a 10-day treatment with natural progesterone, 100 mg 2 times daily (n = 16), or tamoxifen, 10 mg 2 times daily (n = 17). Both treatments alleviated climacteric symptoms, maturated the vaginal epithelium, and decreased follicle-stimulating hormone, luteinizing hormone, and prolactin concentrations while lipid metabolism remained unaltered. In the estrogen-progesterone group 4 women (25%) were persistently amenorrheic, 12 (75%) experienced 1–5 bleedings per year, and 4 women had proliferative endometrium after treatments. In the estrogen-tamoxifen group 11 women (65%) were amenorrheic, 6 (35%) had 1–4 bleedings per year, and 5 had proliferative endometrium. With the present treatment schedules, tamoxifen was more effective than natural progesterone in inhibiting estrogen stimulation of postmenopausal endometrium.
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