Protective Effect of Human Pancreatic Secretory Trypsin Inhibitor on Cerulein-lnduced Acute Pancreatitis in Rats
作者:
Akihiro Funakoshi,
Kyoko Miyasaka,
Atsuo Jimi,
Kenichi Kitani,
Hiroshi Teraoka,
Nobuo Yoshida,
期刊:
Digestion
(Karger Available online 1992)
卷期:
Volume 52,
issue 3-4
页码: 145-151
ISSN:0012-2823
年代: 1992
DOI:10.1159/000200946
出版商: S. Karger AG
关键词: Cerulein;Acute pancreatitis;Pancreatic secretory trypsin inhibitor
数据来源: Karger
摘要:
We examined the protective effect of human pancreatic secretory trypsin inhibitor (PSTI), a specific trypsin inhibitor secreted from pancreatic acinar cells into the pancreatic duct, on cerulein-induced acute pancreatitis in conscious rats. The protective effect of human PSTI-RS, an analogue of PSTI with Arg-44 to Ser substitution which has a longer half-life in vitro, was also examined. Intraperitoneal administration of a pharmacological dose of cerulein to conscious rats induced acute pancreatitis, characterized by light microscopy as cellular disorganization of the acini and interstitial edema. Intravenous infusion of human PSTI (10, 50 or 250μg/rat/h) into rats with cerulein-induced acute pancreatitis decreased their pancreatic wet weight and plasma amylase concentration. It also caused a dose-dependent decrease in vacuoles in acinar cells and interstitial edema. Human PSTI-RS, which has a longer half-life in vivo, was more effective than native PSTI at the same dose rate (10 μg/rat/h) in reducing pancreatitis. These results suggest that human PSTI may have a beneficial effect on acute pancreatiti
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