A Phase 2 Study of Intermittent High Dose Isophosphamide Therapy of Advanced Colorectal Cancer
作者:
John S. Kovach,
Allan J. Schutt,
R.G. Hahn,
R.J. Reitemeier,
Charles G. Moertel,
期刊:
Oncology
(Karger Available online 1974)
卷期:
Volume 29,
issue 1
页码: 34-39
ISSN:0030-2414
年代: 1974
DOI:10.1159/000224886
出版商: S. Karger AG
关键词: Isophosphamide therapy;Cyclophosphamide therapy;Colorectal cancer
数据来源: Karger
摘要:
33 patients with advanced adenocarcinoma of the colon or rectum were treated with isophosphamide given intravenously at a dose of 4 g/m2 every 3 weeks. Patients receiving the full dose in a single infusion experienced severe nausea and vomiting and hemorrhagic icystitis. Those receiving two infusions of 2 g/m2 each 24 h apart, had only mild gastrontestinal and urinary symptoms. Hematologic toxicity was similar for both regimens, consisting of mild and transient leukopenia in approximately 30% of patients. Alopecia occurred in 60% of patients. Central nervous system toxicity manifested as somnolence and disorientation occurred in three patients. Only one objective tumor response lasting 9 weeks was noted in 33 patients treated with isophosphamide.
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