首页   按字顺浏览 期刊浏览 卷期浏览 Pathogenesis of Widened HB AP-SP Complex in Cases of Ig Cerebeliopontine Angle Tumors
Pathogenesis of Widened HB AP-SP Complex in Cases of Ig Cerebeliopontine Angle Tumors

 

作者: Taizo Takeda,   Masaaki Kitahara,   Izumi Sawada,  

 

期刊: ORL  (Karger Available online 1992)
卷期: Volume 54, issue 1  

页码: 15-20

 

ISSN:0301-1569

 

年代: 1992

 

DOI:10.1159/000278935

 

出版商: S. Karger AG

 

关键词: Electrocochleogram;Enhanced negative SP;Efferent cochlear nerve;Cerebeliopontine angle tumor

 

数据来源: Karger

 

摘要:

Pathogenesis of widened AP-SP complexes often noted in electrocochleo-grams (ECochGs) in cases of cerebeliopontine angle tumors remains unclear. As acoustic neuromas usually originate from the vestibular nerve, some changes in this nerve might be involved in producing the broadened wave-form. Effects of lidocaine on the AP-SP complex were investigated in guinea pigs by injecting this Compound into the root exit zone of the vestibular nerve, where the cochlear efferent fibers run together. The AP-SP complex in response to clicks and tone bursts was recorded at the bony wall of the scala vestibuli in the basal turn of the Cochlea. Inactivation of the efferent cochlear fibers resulted in a marked widening of the waveform, independent of the interstimulus intervals (ISIs). This broad wave was composed of a DC shift which was quite similar to the envelope curve of the acoustic Stimuli. Although the effect of activity of the efferent cochlear fibers on negative summating potential (SP) has not been reported in detail, the authors con-cluded that the broad waveform observed in ECochGs in cases with cerebeliopontine angle tumors was caused by enhanced negative SP due to inactivation of efferent cochlear fibers.

 

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