Long-Term Renal Effect of Cisplatin in Man
作者:
Georges Brillet,
Gilbert Deray,
Claude Jacquiaud,
Laurent Mignot,
David Bunker,
Dominique Meillet,
Françoise Raymond,
Claude Jacobs,
期刊:
American Journal of Nephrology
(Karger Available online 1994)
卷期:
Volume 14,
issue 2
页码: 81-84
ISSN:0250-8095
年代: 1994
DOI:10.1159/000168693
出版商: S. Karger AG
关键词: Blood pressure;Chronic renal failure;Cisplatin,;nephrotoxicity;Enzymuria
数据来源: Karger
摘要:
Although the acute nephrotoxicity of cisplatin has been well documented, long-term follow-up studies are scanty. We have evaluated the renal function in 35 patients who have had completed therapy with cisplatin at least 3 months before the study. All patients had normal serum creatinine levels before chemotherapy. Evaluation of renal function included: serum creatinine, glomerular filtration rate (inulin clearance), effective renal plasma flow (p-aminohippurate clearance), urinary β2-microglobulin and N-acetyl-β-D-glucosaminidase excretion, and renal tomography. The median cumulated dose of cisplatin was 603 ± 37 mg/m2. The mean serum creatinine level was 78 ± 21 and 88 ± 3 μmol/l before and after chemotherapy, respectively (p < 0.05). Mean glomerular filtration rate (92 ± 4 ml/min) and effective renal plasma flow (362 ± 21 ml/min) were significantly lower than in controls (110 ± 3 and 436 ± 24 ml/min). The mean enzymuria and the renal size remained within the normal range. In 12 patients who were reevaluated 12 and 24 months later, glomerular filtration rate and effective renal plasma flow remained stable. These results suggest that at usual dosages cisplatin is associated with a nonprogressive loss of renal function which is of a moderate degree.
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