Evaluation of Fosfomycin in an Intensive Care Unit
作者:
A. Pardo Zubiris,
L. Gimeno Blasco,
J. Andonegui Oteiza,
期刊:
Chemotherapy
(Karger Available online 1977)
卷期:
Volume 23,
issue 1
页码: 411-415
ISSN:0009-3157
年代: 1977
DOI:10.1159/000222083
出版商: S. Karger AG
关键词: Various infections;Intensive care unit;Fosfomycin
数据来源: Karger
摘要:
Sensitivity to fosfomycin has been studied and recorded throughout a period of 12 months in the bacteriological isolations originating from this Intensive Care Unit. The 548 samples were biological products obtained from patients admitted to this unit (bronchial exudates, urine, wounds, blood, cava catheters and cere-brospinal fluid). The highest percentage of sensitivity was given by S. aureus coagulase (+), S. fecalis and E. coli (91, 89 and 84% respectively), and the least by P. aeruginosa and Providencia (33 and 8% respectively). A summary is included of 8 seriously ill patients admitted with varied septic processes, produced by germs sensitive to fosfomycin and treated with this, in 5 cases alone and in 3 cases with gentamicin and carbenicillin. Of those who were treated with fosfomycin alone: three were cured, one died on the sixth day through circulatory, respiratory and renal deficiencies and the other with respiratory deficiency. Those treated with the combined antibiotics: two were cured and the other died of sepsis on the fourth day.
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