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Intestinal Mucins in Health and Disease

 

作者: J.F. Forstner,  

 

期刊: Digestion  （Karger Available online 1978）
卷期: Volume 17, issue 3  

页码: 234-263

 

ISSN:0012-2823

 

年代: 1978

 

DOI:10.1159/000198115

 

出版商: S. Karger AG

 

关键词: Blood groups;Carbenoxolone;Cholecystokinin;Colitis;Colon neoplasms;Cycloheximide;Cystic fibrosis;Galactose;Glycoproteins;Goblet cells;Hexosamines;Intestinal mucosa;Intestinal villus;Mucins;Mucus;Peptic ulcer;Puromycin;Secretion;Serotonin;Viscosity

 

数据来源: Karger

 

摘要:

Intestinal mucins are complex glycoproteins which are secreted from goblet cells, and form a gel-like covering over the mucosal surface. They are assumed to provide lubrication and protection of the underlying epithelium against potentially injurious chemicals, enzymes, bacteria and dietary constituents. Recent advances in our understanding of mucin structure, secretion and functional properties are reviewed in this paper. Implications for diseases such as cystic fibrosis, peptic ulcer, malignancy and inflammatory bowel disease are briefly discussed.

 

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