The Skin as an Organ for the Study of the Pharmacology of Neuropeptides
作者:
J.C. Foreman,
期刊:
Skin Pharmacology and Physiology
(Karger Available online 1988)
卷期:
Volume 1,
issue 2
页码: 77-83
ISSN:1660-5527
年代: 1988
DOI:10.1159/000210752
出版商: S. Karger AG
关键词: Skin;Substance P;Tachykinins;Calcitonin gene-related peptide;Mast cells
数据来源: Karger
摘要:
There is good evidence that some vascular effects of inflammation in the skin are neurogenic and involve axon reflexes in the terminal arborizations of C-fibres containing substance P, neurokinin A and calcitonin gene-related peptide (CGRP). Substance P produces dose-related wheal and flare reactions in human skin. Neurokinin A induces wheal but little or no flare and is less potent than substance P. CGRP induces both wheal and flare but is also less potent than substance P. In addition, CGRP induces a slow-onset, intense vasodilatation in human skin which persists for several hours and is associated with leucocyte infiltration: a response which is not seen with substance P. Substance P also releases histamine from mast cells in the skin and the presence or absence of a role for histamine and mast cells in neurogenic inflammation in skin is discussed.
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